Luna Lab for RNA Systems Virology Dept. of Biochemistry & RNA Center, Case Western Reserve University

Publications

Highlighted

Mapping RNA-Protein Interactions with Subcellular Resolution Using Colocalization CLIP
Mapping RNA-Protein Interactions with Subcellular Resolution Using Colocalization CLIP
Soon Yi, Shashi S Singh, Kathryn Rozen-Gagnon, Joseph M Luna
RNA  ·  24 Apr 2024  ·  doi:10.1261/rna.079890.123

All

2024

Mapping RNA-Protein Interactions with Subcellular Resolution Using Colocalization CLIP
Mapping RNA-Protein Interactions with Subcellular Resolution Using Colocalization CLIP
Soon Yi, Shashi S Singh, Kathryn Rozen-Gagnon, Joseph M Luna
RNA  ·  24 Apr 2024  ·  doi:10.1261/rna.079890.123

2023

OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs
Ning Yang, Yi Wang, Shuaitong Liu, Shanza Baseer Tariq, Joseph M. Luna, …, Jenny Zhaoying Xiang, Charles M. Rice, Taha Merghoub, Jedd D. Wolchok, Liang Deng
Journal of Experimental Medicine  ·  05 May 2023  ·  doi:10.1084/jem.20221166
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Danyel Lee, Jérémie Le Pen, Ahmad Yatim, Beihua Dong, Yann Aquino, …, Lluis Quintana-Murci, Charles M Rice, Robert H Silverman, Shen-Ying Zhang, Jean-Laurent Casanova
Science (New York, N.Y.)  ·  10 Feb 2023  ·  pmid:36538032

2022

Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice.
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice.
Mohammad Kabbani, Eleftherios Michailidis, Sandra Steensels, Clifton G Fulmer, Joseph M Luna, …, Markus Grompe, Philip Meuleman, Baran A Ersoy, Charles M Rice, Ype P de Jong
Cell reports  ·  13 Sep 2022  ·  pmid:36103835
Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection
Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection
Ning Yang, Joseph M. Luna, Peihong Dai, Yi Wang, Charles M. Rice, Liang Deng
Nature Communications  ·  29 Mar 2022  ·  doi:10.1038/s41467-022-29308-2

2021

Replication and single-cycle delivery of SARS-CoV-2 replicons
Replication and single-cycle delivery of SARS-CoV-2 replicons
Inna Ricardo-Lax, Joseph M. Luna, Tran Thi Nhu Thao, Jérémie Le Pen, Yingpu Yu, …, Paul D. Bieniasz, John T. Poirier, Margaret R. MacDonald, Volker Thiel, Charles M. Rice
Science  ·  26 Nov 2021  ·  doi:10.1126/science.abj8430
DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2.
DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2.
Mayu O Frank, Nathalie E Blachere, Salina Parveen, Ezgi Hacisuleyman, John Fak, …, Leopolda Silvera, Joseph Masci, Machelle Allen, Charles M Rice, Robert B Darnell
PloS one  ·  25 Jun 2021  ·  pmid:34170927
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
H.-Heinrich Hoffmann, Francisco J. Sánchez-Rivera, William M. Schneider, Joseph M. Luna, Yadira M. Soto-Feliciano, …, C. David Allis, Scott W. Lowe, Margaret R. MacDonald, John T. Poirier, Charles M. Rice
Cell Host & Microbe  ·  01 Feb 2021  ·  doi:10.1016/j.chom.2020.12.009
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
William M. Schneider, Joseph M. Luna, H.-Heinrich Hoffmann, Francisco J. Sánchez-Rivera, Andrew A. Leal, …, Ansgar F. Stenzel, Scott W. Lowe, Margaret R. MacDonald, Charles M. Rice, John T. Poirier
Cell  ·  01 Jan 2021  ·  doi:10.1016/j.cell.2020.12.006

2020

E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
Stephanie L. Sarbanes, Vincent A. Blomen, Eric Lam, Søren Heissel, Joseph M. Luna, Thijn R. Brummelkamp, Erik Falck-Pedersen, H.-Heinrich Hoffmann, Charles M. Rice
Proceedings of the National Academy of Sciences  ·  28 Dec 2020  ·  doi:10.1073/pnas.2015794118

2017

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence
miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence
Yingpu Yu, Troels K. H. Scheel, Joseph M. Luna, Hachung Chung, Eiko Nishiuchi, …, Ian W. Lipkin, Thomas J. Divers, Douglas F. Antczak, Bud C. Tennant, Charles M. Rice
PLOS Pathogens  ·  30 Oct 2017  ·  doi:10.1371/journal.ppat.1006694
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.
Joseph M Luna, Juan M Barajas, Kun-Yu Teng, Hui-Lung Sun, Michael J Moore, Charles M Rice, Robert B Darnell, Kalpana Ghoshal
Molecular cell  ·  20 Jul 2017  ·  pmid:28735896
Mouse models of acute and chronic hepacivirus infection
Mouse models of acute and chronic hepacivirus infection
Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing W. Xiao, Corrine Quirk, …, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. Rice
Science  ·  14 Jul 2017  ·  doi:10.1126/science.aal1962

2016

Present and not reporting for duty: ds<scp>RNA</scp>i in mammalian cells
Present and not reporting for duty: dsRNAi in mammalian cells
Joseph M Luna, Xianfang Wu, Charles M Rice
The EMBO Journal  ·  10 Nov 2016  ·  doi:10.15252/embj.201695933
Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies
Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies
Vyas Ramanan, Kartik Trehan, Mei.-Lyn. Ong, Joseph M. Luna, Hans.-Heinrich Hoffmann, …, Robert E. Schwartz, Kathleen S. Christine, Charles M. Rice, Alexander van Oudenaarden, Sangeeta N. Bhatia
Virology  ·  01 Jul 2016  ·  doi:10.1016/j.virol.2016.04.020
A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration
A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration
Troels K.H. Scheel, Joseph M. Luna, Matthias Liniger, Eiko Nishiuchi, Kathryn Rozen-Gagnon, …, Irene Keller, Rémy Bruggmann, Robert B. Darnell, Nicolas Ruggli, Charles M. Rice
Cell Host & Microbe  ·  01 Mar 2016  ·  doi:10.1016/j.chom.2016.02.007
Mopping up miRNA: An integrated HBV transcript disrupts liver homeostasis by sequestering miR-122
Mopping up miRNA: An integrated HBV transcript disrupts liver homeostasis by sequestering miR-122
Joseph M. Luna, Eleftherios Michailidis, Charles M. Rice
Journal of Hepatology  ·  01 Feb 2016  ·  doi:10.1016/j.jhep.2015.10.023

2015

miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
Michael J. Moore, Troels K. H. Scheel, Joseph M. Luna, Christopher Y. Park, John J. Fak, Eiko Nishiuchi, Charles M. Rice, Robert B. Darnell
Nature Communications  ·  25 Nov 2015  ·  doi:10.1038/ncomms9864
Hepatitis C Virus RNA Functionally Sequesters miR-122
Hepatitis C Virus RNA Functionally Sequesters miR-122
Joseph M. Luna, Troels K.H. Scheel, Tal Danino, Katharina S. Shaw, Aldo Mele, …, Maria Teresa Catanese, Ype P. de Jong, Ira M. Jacobson, Charles M. Rice, Robert B. Darnell
Cell  ·  01 Mar 2015  ·  doi:10.1016/j.cell.2015.02.025

2012

EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency
EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency
Kasandra J Riley, Gabrielle S Rabinowitz, Therese A Yario, Joseph M Luna, Robert B Darnell, Joan A Steitz
The EMBO Journal  ·  30 Mar 2012  ·  doi:10.1038/emboj.2012.63

2011

End game: Getting the most out of microRNAs
End game: Getting the most out of microRNAs
Shihyun You, Catherine L. Murray, Joseph M. Luna, Charles M. Rice
Proceedings of the National Academy of Sciences  ·  09 Feb 2011  ·  doi:10.1073/pnas.1019613108

2009

Human TRIM Gene Expression in Response to Interferons
Human TRIM Gene Expression in Response to Interferons
Laetitia Carthagena, Anna Bergamaschi, Joseph M. Luna, Annie David, Pradeep D. Uchil, …, Walther Mothes, Uriel Hazan, Catherine Transy, Gianfranco Pancino, Sébastien Nisole
PLoS ONE  ·  17 Mar 2009  ·  doi:10.1371/journal.pone.0004894

2008

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle
TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle
Pradeep D Uchil, Brian D Quinlan, Wai-Tsing Chan, Joseph M Luna, Walther Mothes
PLoS Pathogens  ·  01 Feb 2008  ·  doi:10.1371/journal.ppat.0040016